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Hairloss Study Abstract: 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review. |
Title: 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review. Title Abreviation: Eur Urol Date of Pub: 1991 Author: Imperato-McGinley J; Issue/Part/Supplement: -HEADING- Volume Issue: 20 Suppl 1 Pagination: 78-81 MESH Headings: Aged; Androstenes (*TU); Azasteroids (*TU); Comparative Study; Double-Blind Method; Human; Male; Middle Age; Prostatic Hyperplasia (DT); Pseudohermaphroditism (*DT/EN); Stanolone (ME); Testosterone 5-alpha-Reductase (*AI/*DF/ME); -RN-; Journal Title Code: ENM Publication Type: CLINICAL TRIAL Date of Entry: 920211N Entry Month: 9204 Country: SWITZERLAND Index Priority: 2 Language: Eng Unique Identifier: 92104209 Unique Identifier: 92104209 ISSN: 0302-2838 Abstract: Male pseudohermaphrodites (MPHs) with inherited 5 alpha-reductase deficiency and decreased dihydrotestosterone production have a global defect in 5 alpha-metabolism affecting both C19 androgen metabolism and C21 steroid metabolism. However, the decreased 5 alpha-reduction of testosterone to dihydrotestosterone is the only impaired steroid conversion to have clinical consequences, e.g., ambiguous genitalia, impaired prostate differentiation and development, and decreased facial and body hair. The 5 alpha-steroid metabolite profile in the MPHs was compared with that of men with benign prostatic hyperplasia who were administered varying doses of the 5 alpha-reductase inhibitor finasteride. Finasteride was found to be a potent inhibitor of both C19 androgen and C21 5 alpha-steroid metabolism affecting both hepatic and peripheral 5 alpha-metabolism. The 5 alpha-steroid metabolite profile was strikingly similar to that of MPHs with inherited 5 alpha-reductase deficiency. The data suggest that a 5 alpha-reductase gene codes for an enzyme with affinity for multiple steroid substrates. Abstract By: Author Address: Department of Medicine, Cornell University Medical College, New York, NY.
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